Learn about T helper 2 cells (Th2) and their role in innate immunity, including differentiation and tools for study.

CD4 + T cells have TCRs with an affinity for Class II MHC, and CD4 is involved in determining MHC affinity during maturation in the thymus. Class II MHC proteins are generally only found …

The Th1/Th2 concept describes the differentiation of CD4 + T-helper cells into either a Th1 or Th2 subset, each directing specific immune response pathways [59].

T helper 2 (T H 2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, …

Oct 30, 2017 · This Review describes our current understanding of the mechanisms regulating T helper 2 (TH2) cell development and function.

TH2 cells do not directly eliminate pathogens but instead guide other immune cells to perform defensive actions. Their activity is tightly regulated to ensure an effective, controlled immune …

Mar 11, 2025 · T helper 2 (Th2) cells are a distinct subset of CD4+ T lymphocytes that play a crucial role in humoral immunity and host defense against extracellular pathogens, particularly …

Aug 12, 2025 · Th1 and Th2 are the primary branches, directing distinct arms of the immune system. Th1 cells promote cellular immunity, helping to eliminate viruses and intracellular …

Aug 9, 2022 · Type 2 helper T (Th2) cells, a subset of CD4 + T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin …

Th2, or T helper type 2, cells are a subset of CD4+ T lymphocytes that play a crucial role in orchestrating the immune response, particularly against extracellular pathogens like parasites …