Findings from receiver operating characteristic analysis identified transferrin cutoff values of 194.0 mg/dL for differentiating active AAV from remission AAV and 259.5 mg/dL for distinguishing those ...

The prevalence of irregular red cell alloantibodies was 8.04% in pediatric patients, with anti-E and anti-Mi antibodies the most common. Pediatric patients can develop irregular, non-ABO red cell ...

The researchers identified 158 mtDNA variants across samples, with a higher variant burden in stillbirth cases without cardiac conduction system abnormalities. Mitochondrial DNA (mtDNA) alterations ...

For PBC, the phase 3 GLISTEN trial of linerixibat showed a significant pruritus improvement, with an adjusted mean difference of –0.72 on the Worst Itch Numeric Rating Scale. Ileal bile acid ...

The risk of occurrence of the clinical trial's endpoints was lower in patients with PPF treated with 9 mg or 18 mg twice a day compared with those given the placebo. Treatment with nerandomilast at a ...

Peripheral oxygen saturation recovery time and a modified gender-age-physiology index could predict the risk of overall adverse events in patients with IPF. Incorporating peripheral oxygen saturation ...

In a cross-sectional study, the researchers reported psychiatric comorbidities in 46.5% of 43,270 adults with neurofibromatosis. The most common psychiatric comorbidities included mood disorders (22.1 ...

Abby Bronson advocates for those with Becker muscular dystrophy, which can have severe consequences on mobility and quality of life. Larry Luxner, senior correspondent for Rare Disease Advisor, ...

The high-output heart failure cohort was characterized by an increased frequency of secondary MF and lower baseline hemoglobin levels. Echocardiographic high-output heart failure in patients with ...

Among those with ATTR, the sodium-glucose cotransporter 2 inhibitor group saw a nearly 50% reduction in all-cause mortality compared with controls (9.43% vs 19.2%; HR, 0.52). Sodium-glucose ...

The responder rate was 57%, and five patients (36%) achieved complete seizure freedom. The addition of stiripentol to standard-of-care therapies may offer meaningful seizure reduction for patients ...

Autoimmune hepatitis overlap syndromes (PBC/AIH, PSC/AIH) in Arabs show treatment response, remission, and relapse-free survival comparable to standalone AIH. Patients with autoimmune hepatitis (AIH) ...