RMD Open

Heat-not-burn tobacco induces protein post-translational modifications and apoptosis in bronchial cells: possible role in rheumatoid arthritis

Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid ...
RMD Open

Pre-arthritis stages of rheumatoid arthritis: from pathology to precision prevention

Over the last decade, the outlook for patients with rheumatoid arthritis (RA) has improved, but there is growing interest in ...
RMD Open

Early methylprednisolone pulses and prevention of long-term damage accrual in active systemic lupus erythematosus: a propensity score analysis of the Lupus–Cruce…

Objective Methylprednisolone pulses (MP) help achieve prolonged remission in patients with moderate–severe systemic lupus ...
RMD Open

Sustaining remission in rheumatoid arthritis: the role of clinical deep remission and its implications for drug tapering

Objective While sustained remission is the treatment goal for rheumatoid arthritis (RA), its long-term remission remains ...
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Machine learning-based multiclass model for autoimmune disease diagnosis and classification through nailfold videocapillaroscopy features

Objective To develop and validate a predictive model for distinguishing controls (Ctr), rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) based on nailfold videocapillaroscopy (NVC) ...
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Do high rheumatoid factor levels impact response to certolizumab pegol in patients with inadequately controlled rheumatoid arthritis? A post hoc analysis of the phase IIIb ...

Objectives To assess the impact of rheumatoid factor (RF) levels and previous inadequate responses/intolerance to tumour necrosis factor inhibitors (TNFi-IR) on the efficacy of certolizumab pegol (CZP ...
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Effects of upadacitinib or adalimumab on pain in rheumatoid arthritis and psoriatic arthritis: results from randomised phase 3 studies

Introduction Patients with rheumatoid (RA) or psoriatic (PsA) arthritis can experience debilitating pain. Methods Post hoc analyses of phase 3, double-blind studies in patients with active disease ...
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Circulating monocytes from systemic sclerosis patients with progressive interstitial lung disease preferentially express M2 phenotype markers: in vitro and ex vivo study

Objective To characterise phenotype and functional profibrotic M2 markers in circulating monocytes and cultured monocyte-derived macrophages (MDMs) from systemic sclerosis (SSc) patients (pts) with ...
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Strengths and limitations of the EULAR definition for difficult-to-treat rheumatoid arthritis

The management of rheumatoid arthritis (RA) has significantly improved, but a substantial number of patients still experience persistent disease activity, leading to the concept of ‘difficult-to-treat ...
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Rheumatic and musculoskeletal disorders in musicians: risks, adaptations and management

Music therapy is recognised as a complementary or alternative therapy for osteoarthritis and fibromyalgia, but playing music can have health repercussions for musicians in the field of rheumatology.
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Long-term safety and efficacy of upadacitinib or adalimumab in patients with rheumatoid arthritis: results through 3 years from the SELECT-COMPARE study

Objectives To assess the long-term safety and efficacy of the Janus kinase inhibitor upadacitinib versus adalimumab over 3 years in the ongoing long-term extension (LTE) of SELECT-COMPARE, a ...
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Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region

Methods We paired summary statistics from genome-wide association studies (GWASs) of diffuse large B cell lymphoma, follicular lymphoma (FL), chronic lymphocytic leukaemia (CLL) and marginal zone ...