In sweeping attacks that started early Friday, Israel has struck at the regime in Tehran, targeting Iranian nuclear and military assets. The Israeli strikes have killed more than 70 people, including four top security chiefs, and damaged Iran’s main nuclear site at Natanz.

The United States is the main international backer of Israel, Iran's biggest regional foe. It is also a close ally of Sunni Gulf monarchies which for years pursued their own rivalry with the Islamic Republic, seeing it as their main regional threat.

Iran launched dozens of ballistic missiles toward Israel on Friday night in retaliation for Israel's surprise attack early Friday. Israel struck at the heart of the Iran's nuclear program, killing several nuclear scientists as well as high-ranking military leaders, according to Israeli officials.

The two sides were scheduled to meet for a sixth round of negotiations on Sunday. Oman, which was set to host the talks, said on Saturday that this round had been canceled.

The United States has pulled some diplomatic staff and military families out of the Middle East, citing unspecified regional security risks.

Countries trade strikes as tensions grow over larger Middle East conflict - Iranian missiles struck an apartment building in the Galilee region, killing four people, as the countries exchanged fire

National security experts warn that Israel's attack on Iran shows why Chinese land and asset purchases in the U.S. pose a significant threat to American security.

Interviews with half a dozen senior Iranian officials show that they were not expecting Israel to strike before another round of talks.