If 49ers are to hit the ground running on Sept. 7, these eight plays must be protected until the regular season begins.

Christian McCaffrey, Kyren Williams, & Najee Harris have carried heavy workloads in their NFL careers. Injury concerns will raise caution in fantasy football.

McCaffrey is not in line to play in Saturday's preseason opener against the Broncos, Eric Branch of the San Francisco Chronicle and David Lombardi of SFStandard.com report. With Isaac Guerendo ...

The 49ers likely have no intention of playing starter Christian McCaffrey in the preseason, backup Isaac Guerendo is out for ...

49ers head coach Kyle Shanahan was asked on Monday if there is any concern from the coaching staff regarding the severity of Jennings' calf injury and if it could play out similarly to Christian ...

The San Francisco 49ers officially place one of their veteran running backs on the season-ending IR ahead of the 2025-26 ...

When the 49ers offense is healthy, it's one of the best in the NFL. Unfortunately, their offense wasn't healthy last year, and it isn't healthy now.

Christian McCaffrey credited his wife, Olivia Culpo, for taking care of their newborn daughter while he's at San Francisco ...

The 49ers started 3-4 and traded for Christian McCaffrey, finishing 13-4 and reaching the conference championship game. They started 5-3 last season and ended up 12-5, reaching the Super Bowl.

The 49ers head into the season deep along the offensive and defensive lines but light at wide receiver and quarterback.

Evaluating the risk-factors of Christian McCaffrey and his ability to be drafted in the first round of your fantasy football ...

Two weeks after welcoming his first child into the world, San Francisco 49ers running back Christian McCaffrey says he's on ...