Intracranial aneurysms are common, and the risk of rupture is influenced by size, location, morphology, and factors such as ...

To access our most recent research and articles on Covid-19 and Covid-19 vaccines, please visit the NEJM Coronavirus (Covid-19) page. To realize the potential of recently developed Covid-19 ...

This review article series focuses on fundamental and emerging concepts in nutrition, from the basic “pharmacodynamics” of food to evolving understanding of the gut and immunity and the role ...

The case description for a Case Records of the Massachusetts General Hospital appears below. A 61-year-old man presented with hypoxemic respiratory failure and shock 10 weeks after kidney ...

In a pragmatic trial, we randomly assigned adults 65 years of age or older who were patients in the Department of Veterans Affairs health system and had been receiving hydrochlorothiazide at a ...

Gestational age is the major determinant of neonatal death (death within the first 28 days of life) in preterm infants. The joint effect of gestational age and Apgar score on the risk of neonatal ...

Aldosterone synthase controls the synthesis of aldosterone and has been a pharmacologic target for the treatment of hypertension for several decades. Selective inhibition of aldosterone synthase ...

Hormone absence or inactivity is common in congenital disease, but hormone antagonism remains controversial. Here, we characterize two novel homozygous leptin variants that yielded antagonistic ...

Multiple loss-of-function alterations in genes that are involved in DNA repair, including homologous recombination repair, are associated with response to poly ...

An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection ...

Dr. Mallory C. Mandel (Pediatrics): A 16-year-old girl was admitted to this hospital because of abdominal pain. The patient had been in her usual state of health until 4 weeks before the current ...

Schistosomiasis is a parasitic neglected tropical disease that is estimated to currently infect more than 140 million persons. 1,2 Ninety percent of the disease burden is in sub-Saharan Africa ...