Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a side ...

Genome‐, transcriptome‐ and proteome‐wide measurements provide insights into how biological systems are regulated. However, fundamental aspects relating to which human proteins exist, where they are ...

During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...

Only about 5 years after the first preclinical proof of concept for gene therapy of otoferlin-related auditory synaptopathy (Al-Moyed et al, 2018; Akil et al, 2019), preliminary reports from several ...

Cellular DNA barcoding has become a popular approach to study heterogeneity of cell populations and to identify clones with differential response to cellular stimuli. However, there is a lack of ...

Multiple sequence alignments are fundamental to many sequence analysis methods. Most alignments are computed using the progressive alignment heuristic. These methods are starting to become a ...

The protein expression profile of ACE2, suggested as host receptor for SARS‐CoV‐2, is assessed in various human organs. Notably, limited ACE2 expression is observed in the respiratory system both on ...

The recent scandal surrounding Facebook and Cambridge Analytica 5 shows that these aspects of security and privacy are often not taken into account. Cambridge Analytica, a British consulting firm, was ...

A single injection of a diabetes drug effectively reduced brain damage and significantly improved disabilities and survival of the treated mice. The drugs activated pathways in cells of the brain that ...

For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The X10 expansion microscopy protocol ...

Immunocytokines, comprising various antibody formats and cytokines, have been reported for cancer therapy (Gout et al, 2022). Targeting efficacy was shown to be determined not only by the antibody but ...