Because blood is so easy to sample, scientists like to screen this biofluid when looking for disease associations. Alas, that is not the best approach for neurodegenerative disorders, according to ...

Certain mutations in the GBA1 gene are the most common genetic risk factors for Parkinson’s disease; even so, most people with these variants never develop PD. Now, scientists led by Anthony Schapira ...

Scientists are trying to parse the cellular interactions that foment ARIA during amyloid immunotherapy. At last month’s AD/PD conference in Copenhagen, Denmark, speakers highlighted the role of both ...

Scientists are getting closer to figuring out how amyloid immunotherapy causes ARIA, and perhaps how to prevent it. At last month’s AD/PD conference in Copenhagen, Denmark, the spotlight was on innate ...

Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...

Interconnected networks of neurons—i.e., circuits—are the basis of brain function, and astrocytes support synapses within them. They also form networks of their own, passing messages and sharing ...

Early onset familial Alzheimer disease (eFAD) is hereditary and marked by Alzheimer disease symptoms that appear at an unusually early age. Symptoms can start in a person's thirties, forties, and ...

"The neurologist diagnosed conversion disorder (see Medline). I should not have believed that. We went to counseling sessions for a year but nothing happened." —Caregiver. Families with eFAD tell ...

In 2009, Robert Baloh and colleagues reported a transgenic mouse model of ALS based on the overexpression of mutant TARDBP (TDP-43) (Wegorzewska et al., 2009). These mice developed several features of ...

Parkin Flx/Flx mice allow for conditional knockout of the Prkn gene using a Cre-loxP recombination system (Shin et al., 2011). This approach aims to overcome the developmental compensation seen in ...

The dbl-PAC-Tg(SNCA A53T) +/+;Snca-/-model, referred to here as double-transgenic mice, are mice lacking endogenous α-synuclein (Snca knockout mice) that were crossed with two homozygous transgenic ...

Score another one for amyloid immunotherapy. The anti-pyroglutamated amyloid antibody donanemab has posted positive top-line results in the Phase 3 Trailblazer-Alz2 study, according to an Eli Lilly ...