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Predictions, picks and odds for NFL Week 16 game

NFL Straight-Up Moneyline Picks for Every Game in Week 16

Week 15 of the 2025 NFL season is in the books, which means we have just three weeks to go before the postseason officially begins.

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NFL Week 16 confidence picks: Lock in the Texans against the Raiders

SportsLine · 13h

2025 NFL Week 16 odds, score predictions: SportsLine AI reveals picks for every game

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2025 NFL Week 16 rushing yards predictions and player prop bets

Week 16 of the NFL regular season is coming up -- which players will rack up the most rushing yards in the league?

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Announcers revealed for Jaguars vs. Broncos Week 16 matchup

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Bengals vs Dolphins Predictions - Early Picks & Odds for Week 16

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Prisco's Week 16 NFL picks: Seahawks top Rams on 'TNF,' Packers edge Bears, Jaguars upset Broncos

There's nothing like a good hot streak in December when it comes to picking NFL games. For me, it's been a bit of a heater. I went 11-5 both straight up and against the spread las

NFL Week 16 staff picks: Seahawks-Rams showdown for NFC supremacy

It's "Butterfly Effect" season in the NFL, and nearly every game has downstream effects on someone's playoff hopes.