The President of the Commission has spoken with the Israeli leader, to whom she has also conveyed that "the humanitarian situation in Gaza is unacceptable" and that aid must "arrive immediately". "Israel has the right to defend itself.

Experts suggest the U.S. has a strategic opportunity to leverage Iran's weakened position for a nuclear deal after Israel's targeted strikes on Iranian nuclear and military sites.

All night people in Israel have been braced for more rockets. Just before 01:00 the Israeli military announced that it was striking missile sites in Iran, and instructed residents to move closer to shelters. Four hours later the response came – with what felt like the largest barrage so far of this conflict.

Iran conflict could open opportunities for Russia to possibly become a power broker to help end the confrontation.

A statement released by Secretary of State Marco Rubio expressed no solidarity with Israel. The response may reflect a certain irritation with Netanyahu, who, by ordering the strikes, has undermined negotiations with Tehran that Trump relaunched in March.

US is involved in stopping Iranian missile and drone fire; the UK and France are not known to participate, but have signaled they could

In Israel, rescue teams combed through rubble of residential buildings destroyed by Iranian missiles, using sniffer dogs and heavy excavators to look for survivors after at least 10 people, including children, were killed, raising the two-day toll to 13.