Natural DNA is often double-stranded. Yet, there exists another, lesser-known class of interactions between DNA. These so-called normal or reverse Hoogsteen interactions allow a third strand to join ...
Researchers have developed a method to program the spatial organization of double-stranded DNA by incorporating Hoogsteen interactions. Researchers at Aarhus University (Denmark) have developed a ...
Triplex DNA structures form when a third strand of DNA binds to the major groove of a DNA double helix. While these structures are important for gene regulation, they can also contribute to genomic ...
Biosensor uses pH-responsive DNA nanoswitches for highly sensitive bladder cancer detection in urine
A study published in ACS Nano presents a novel biosensor for the isothermal, highly sensitive detection of bladder cancer biomarkers—miRNAs, short non-coding RNAs that regulate gene expression—using ...
Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA. However ...
(Nanowerk News) A human cell harbors roughly 2 meters of DNA, encompassing the essential genetic information of an individual. If one were to unwind and stretch out all the DNA contained within a ...
Figure 2: New research shows that by using a new method called triplex origami one can create triple DNA helices that can bend or "fold" DNA in into compact structures. Illustr: Minke A. D. Nijenhuis ...
Figure 3: Triplex-mediated folding of dsDNA, a) A dsDNA sequence containing triplex-forming domains (coloured) is folded by four TFO strands, i.e. single-stranded DNA acting as staples, into a hairpin ...
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