Scientists often describe life as a series of chemical reactions. Pallav Kosuri, Ph.D., describes life as movement. Chemical ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA. Within a few hundred milliseconds, the DNA double helix unwinds to form a ...

A team led by researchers at UT Southwestern Medical Center has developed deep learning models to identify a simple set of rules that govern the activity of promoters—regions of DNA that initiate the ...

Every living cell, from the simplest bacterium to a human neuron, relies on the same basic machinery to read, interpret, and use its DNA. This molecular machinery is so fundamental that life as we ...

For an organism to function properly, genes have to be turned on or off in the right places at the right times. The machinery in our cells has a variety of ways to control gene expression, one of ...

Transcription factors are genes that, once expressed, can influence the activity of other genes, sometimes many other genes. There are hundreds of transcription factors in human cells that we know of, ...

Transcription-coupled DNA damage repair represents a specialised branch of nucleotide excision repair that ensures rapid removal of lesions from the transcribed strand of active genes. When RNA ...

Transcription factors are central controllers of gene expression during development, directing cells towards specific fates by binding to regulatory DNA elements and recruiting chromatin-modifying ...

Elizabeth Campbell studies the molecular machinery that all living cells use to read and transcribe their genetic instructions. Her lab is finding new ...

While scientists have studied the molecular steps involved in gene expression for decades, many questions still remain about this fundamental process. To transcribe genes, RNA polymerase II (RNA Pol ...

Gene silencing refers to any mechanism that turns down or switches off the expression of a specific gene so that less of its protein, or none at all, is produced. Crucially, the gene's DNA is left ...