Because DNA replication and chromosome segregation are unrelated processes, the systems that maintain their interdependence must be based on intracellular signalling rather than direct biochemical ...
The spindle checkpoint signalling cascade prevents anaphase onset until all chromosomes are correctly attached, through their kinetochores, to spindle microtubules. Molecular interactions between ...
The error-free distribution of genetic material during cell division is important for preventing the development of tumor cells. Prof. Erich Nigg's research group at the Biozentrum, University of ...