RNA viruses are constrained in genome size as a result of limitations from packaging and mutational burden 1. Due to these constraints it is quite common for viral genomes to encode multifunctional ...

Many positive strand RNA viruses encode helicases, but their distinct functions in viral replication cycles is poorly understood. Here, we identify a mutation in the helicase domain of HCV ...

Combining bioinformatics and experimetal approaches, researchers have discovered replication hubs for human norovirus, the leading cause of viral gastroenteritis accounting for an estimated 685 ...

For decades scientists have recognized that human immunodeficiency virus (HIV) is a formidable viral pathogen. After years of probing work and extensive experimentation, a Yale research team has ...

Human norovirus, a positive-strand RNA virus that is the leading cause of viral gastroenteritis accounting for an estimated 685 million cases and approximately 212,000 deaths globally per year, has no ...

A team of scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the University of Regensburg has unveiled insights into how HIV-1, the virus responsible for ...

Bacteriophages, or phages for short, are viruses that infect bacteria. Using phages therapeutically could be very useful in fighting antibiotic-resistant pathogens, but the molecular interactions ...

During viral reproduction, the influenza polymerase (top left, in blue) scans along the ribonucleoprotein helix to produce messenger RNA. Credit: Science Like a camera-shy teenager, influenza’s ...

The expression of symptoms of viral infections is a byproduct of complex virus-host molecular pathways. These remain largely unknown, especially in the case of fungus-virus pathogen systems. Fungal ...

If your holiday season activities include a luxury cruise or feasting on raw oysters, then beware: Norovirus, a gastrointestinal RNA virus that can cause nausea and diarrhea, could be an unwelcome ...

Using genomics, evolutionary biologists test several hypotheses on the origin of viruses. New evidence suggests they may have emerged more times than previously thought. Corroborating the virus-first ...