In two phase 3 induction trials (U-EXCEL and U-EXCEED), we randomly assigned patients with moderate-to-severe Crohn’s disease to receive 45 mg of upadacitinib or placebo (2:1 ratio) once daily for 12 ...
Mirikizumab, a p19-directed antibody against interleukin-23, showed efficacy in the treatment of ulcerative colitis in a phase 2 trial. We conducted two phase 3, randomized, double-blind, ...
Randomized Phase III Postoperative Trial of Platinum-Based Chemotherapy Versus Capecitabine in Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy: ECOG-ACRIN ...
In the article that accompanies this editorial, 15 the Organ Preservation in Rectal Adenocarcinoma (OPRA) trial investigators report the first results of this important study; OPRA is one of the few ...
Chemotherapy is a drug therapy that’s used to treat many different types of cancer. Chemicals in chemotherapy drugs target cells that rapidly divide, such as cancer cells. They may also target healthy ...
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