Eukaryotes possess several clamp loaders comprising four common subunits and a fifth subunit unique to each complex. The RFC-A–E clamp loader loads the PCNA clamp at 3′-recessed structures for DNA ...

The process of DNA replication relies on the coordinated action of a ring‐shaped sliding clamp and its specialised loader complexes. Sliding clamps, typified by proliferating cell nuclear antigen ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

The results of this collaborative project overturn some conventional wisdom about how the DNA repair process works. DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts ...

The DNA damage response is essential for maintaining genome integrity. When DNA damage or replication stress occurs, a checkpoint signaling pathway is activated to arrest the cell cycle and initiate ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, actually plays a key role in ensuring fast and reliable replication—an insight ...