A first-in-human clinical trial of an immune rejuvenation therapy designed to restore the function of worn-out T cells is ...

CAR-T-cell therapy has made significant strides in treating hematological malignancies, yet its efficacy is often hampered by suboptimal T-cell functionality, marked by weak antitumor capabilities and ...

Just as the human body relies on organs such as the heart, lungs and intestines to carry out specialized functions, cells contain organelles (‘little organs’) that carry out essential processes and ...

For some people, cancer immunotherapies are life-changing. These treatments can turn the body's own immune system against a ...

An engineered viral protein enhanced the anticancer function of T cells in mice, suggesting a new strategy to improve immunotherapy. Courtney and his team sought to exploit this property of TIP to ...

Researchers at UT Southwestern Medical Center led a study to develop a computational method that reveals how immune cells ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

T cells are essential components of the immune system and play critical roles in immune responses against infections, tumors, and autoimmune diseases. T cells are highly heterogeneous, with distinct ...

A new Review reveals how aging can push the immune system into a paradoxical state, weaker against threats yet more prone to attacking the body’s own tissues.