Celiac disease, also called celiac sprue, is a condition that affects mostly the small intestine, although it can have consequences throughout the body. People with celiac disease experience digestive ...

Celiac disease is a chronic, immune-mediated, systemic disorder caused by intolerance to gluten — a protein present in rye, barley, and wheat grains — that affects genetically predisposed individuals.

This informational guide, part of PS's Condition Center, lays out the realities of this health concern: what it is, what it can look like, and strategies that medical experts say are proven to help.