Dr. Adil Shamoo does an admirable job of debunking the legitimacy of using "equipoise" to justify the conduct of phase 1 clinical trials and, by extension, phase 2 and 3 clinical trials. [1] To the ...

RCTs incorporate several methodological characteristics intended to maximize the validity of conclusions about the efficacy and safety of the intervention under study. 1 First, they employ a ...

Long-Term Follow-Up of the Prospective Randomized AATT Study (Autologous or Allogeneic Transplantation in Patients With Peripheral T-Cell Lymphoma) Novel cancer drugs can produce higher and more ...

Clinical equipoise, or uncertainty about which treatment is best for a patient, is widely viewed as essential for an ethical RCT. The authors argue that clinical trials that violate equipoise are ...

A seminal paper by Miller and Brody [1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. Their paper argued that the concept of equipoise (also ...