Researchers at the UCLA Jonsson Comprehensive Cancer Center have identified a new role for a protein called extracellular signal-regulated kinase (ERK) in a pathway activated by interferon-gamma that ...
Extracellular Signal Regulated Kinase (ERK) plays an important role in multiple cell signaling processes, by catalyzing the phosphorylation of a variety of substrates. The enzyme itself is activated ...
Clinical efficacy of sunitinib as post-operative adjuvant therapy in patients with high-risk renal cell carcinoma. Incidence of severe nephrotoxicity with cisplatin vs. non-cisplatin regimens: A ...
Results of pooled analyses from two phase III trials of 1,085 patients (pts) with advanced melanoma: Oblimersen (OBL) plus dacarbazine (DTIC) versus DTIC alone. Background: The RAF/MEK/ERK pathway is ...
A team of researchers from the Badalona Applied Research Group in Oncology (B·ARGO) and the Urologic Tumours Unit of the Institut Català d'Oncologia (ICO) and the Germans Trias i Pujol Research ...
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A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular ...
Two of the most common genetic alterations in liver cancer have been shown to act as powerful partners in crime, according to a new study published in Cancer Cell International. Researchers at Kyung ...
ERAS-007 100 mg BID-QW + encorafenib + cetuximab (EC) in EC-naïve patients with BRAFm CRC showed a 50% (3/6) response rate (2 cPR, 1 uPR), reinforcing ERAS-007 as a potential best-in-class ERK ...
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