A multicenter, double-blind, placebo-controlled study conducted over 2 years enrolled 303 patients ages 18 to 55 years with recent CIS suggestive of MS. Disease activity was observed in a smaller ...

Optic nerve involvement is common among patients presenting with CIS of MS. Adding the optic nerve as a fifth site for dissemination in space fulfillment increases the sensitivity, decreases the ...

January 30, 2010 — Tears may one day replace cerebrospinal fluid in diagnosing multiple sclerosis, report researchers. The new isoelectric focusing technique detects oligoclonal bands in eye fluid and ...

A prospective study of first-degree relatives of patients with MS found that this high-risk population faces significantly ...

Radiologically isolated syndrome (RIS) involves MS-like lesions on MRI without clinical symptoms, with a significant risk of progression to MS. Updated 2023 RIS criteria improve diagnostic accuracy, ...

Paramagnetic rim lesions may help assess MS risk in people with radiologically isolated syndrome before symptoms appear.

Multiple sclerosis (MS) is characterized by a broad array of symptoms. Despite this variability, most individuals with MS will exhibit a distinct set of symptoms during their initial clinical attack.