In our laboratory, we have used HR-CGH as a screening method for cryptic chromosomal imbalances for several years. In an initial study, we found a cryptic chromosomal imbalance in 5 out of 50 patients ...

Comparative genomic hybridization (CGH) was developed to identify pathogenic DNA copy-number changes (e.g., duplications, deletions) on a genome-wide scale, and to map these changes to genomic ...

Array CGH has been implemented using a wide variety of techniques. The initial approaches used arrays with elements produced by spotting DNA obtained directly from large-insert genomic clones such as ...

Roche NimbleGen, Inc. has launched NimbleGen Comparative Genomic Hybridization (CGH) microarrays in a 12x135K format for analysis of DNA copy number variation. NimbleGen CGH 12x135K arrays will allow ...

Comparative genomic hybridization (CHG) provides the densest coverage of probes for CNV detection, but the traditional technique using bacterial artificial chromosome arrays is time consuming and not ...

SANTA CLARA, Calif.--(BUSINESS WIRE)--Agilent Technologies Inc. (NYSE:A) today announced that scientists using the company’s comparative genomic hybridization (CGH) technology have shown that cancer ...

Expert Rev Mol Diagn. 2012;12(3):253-264. Cytogenetics can detect clonal CNAs not identified using arrays when they occur in less than 20–30% of metaphases; Arrays cannot detect copy neutral balanced ...

Early efforts to examine genomic changes in the clinical setting relied on cytogenetic techniques such as chromosome karyotyping, a widely used approach to examine chromosomes and identify changes ...

This is a preview. Log in through your library . Abstract In the analysis of data generated by change-point processes, one critical challenge is to determine the number of change-points. The classic ...

MDS and AML are hematopoietic diseases driven by somatically acquired genetic mutations. Cytogenetic alterations at diagnosis remain one of the most powerful prognostic factors in MDS and AML and ...