Lipids Open the Door. Microglial cells treated with unlipidated (top) or lipidated (bottom) ApoE (yellow) along with fluorescently tagged Aβ (green). Lipidated ApoE was more readily internalized and ...

New research shows that microglia, which usually clear debris, cause harmful inflammation in the presence of APOE4 protein.

They took mice genetically predisposed to overproduce amyloid and modified them to carry the human APOE gene with the Christchurch mutation. Then, they injected a tiny bit of human tau into the ...

The link between lipid metabolism and glaucoma pathophysiology could guide future research and treatment strategies.

Taurine treatment significantly decreased plaque areas in the carotid artery, reduced Masson’s Trichrome staining, and lowered the ratio of anti-α-SMA to anti-CD68 staining in ApoE −/− mice.

Taurine may decrease atherosclerotic plaque size and enhance vascular stability, as shown in studies on humans and mice. Previous research has suggested that taurine supplementation could help slow ...

Patrizia Agostinis (VIB-KU Leuven) has found that melanoma cell populations protect themselves from a form of cell death called ferroptosis by secreting the lipoprotein apolipoprotein E (ApoE).

The mouse model not only carries human APOE genes, but the team also transplanted human neurons producing the APOE4 protein into the brains of mice. On removing microglia, they discovered that the ...

A team of scientists has found that the presence of the APOE4 protein -- the most important genetic risk factor for Alzheimer ...

Previous studies suggest that taurine supplementation may attenuate atherosclerosis by reducing lipid levels. However, energy drinks containing taurine have been shown to increase blood pressure, a ...