The Tennessee Titans fell to 2-12 to the San Francisco 49ers (10-4) in Week 15 by a score of 37-24. The latest loss came one week after Tennessee won for only the second time this season on the road against the Cleveland Browns (3-11).

Preview the San Francisco 49ers' NFL week 15 matchup with the Titans, including betting odds, tips, trends, and game information.

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The Titans Wire staff offer their picks and predictions ahead of a Week 15 game between the Tennessee Titans and San Francisco 49ers.

Things haven't been easy for the San Francisco 49ers on Sunday at Levi's Stadium against the Tennessee Titans. They had a ton of offensive success in the first half, but their 5.6 yards per play were outdone by a whopping 6.

The San Francisco 49ers will look to continue their push for the NFL playoffs when they host the Tennessee Titans on Sunday. San Francisco (9-4) is hot on the tails of the Los Angeles Rams and Seattle Seahawks in the NFC West, while Tennessee (2-11) is in contention to earn the first overall pick in next year's NFL Draft.

The Tennessee Titans are back in the loss column after falling 37-24 to the San Francisco 49ers in Week 15 at Levi's Stadium. The Titans were trailing for the entire game against the Niners, but they had a good fight against the Niners.