Kickoff from Santiago Bernabeu Stadium in Madrid is set for 3 p.m. ET. The hosts are -500 favorites (risk $500 to win $100) on the 90-minute money line in the latest Real Madrid vs. Osasuna odds, while Osasuna are +950 underdogs.

The 2025-26 La Liga season is here, as Real Madrid and Atletico Madrid are fighting to retake the division crown from Barcelona.

Then there's Real Madrid, who came out on top 32.1% of occasions, meaning the top two in Spain combine for more than three quarters of the triumphs. For Los Blancos, their worst finish was down in 13th. Atletico Madrid were the only other side with a 10% or more probability, finishing first 11.7% of the time but also coming as low as 17th.

Barcelona has kicked off its La Liga title defense with a 3-0 victory against nine-man Mallorca. Raphinha scored early by heading in a cross from Lamine Yamal in the seventh minute.

The Catalans kicked off their Spanish title defense at the Estadi Mallorca Son Moix, taking on Mallorca in the first of three consecutive away matches to open their 2025–26 campaign. Barcelona picked up right where they left off last season, scoring two goals in the first 23 minutes of the clash.

Barcelona is back in action for the 2025-26 La Liga season, with their first match kicking off this week. ESPN+ offers a wide array of matches throughout the season, including every La Liga match during the 2025-26 season. As the 2025–26 La Liga season kicks off, fans are bracing for another thrilling campaign full of drama and surprises.

Barcelona have faced a real uphill battle in returning to the financial 1:1 rule, and La Liga’s strict financial audits and clauses have only further complicated matters and distanced them from the