Experts suggest the U.S. has a strategic opportunity to leverage Iran's weakened position for a nuclear deal after Israel's targeted strikes on Iranian nuclear and military sites.

US is involved in stopping Iranian missile and drone fire; the UK and France are not known to participate, both both have signaled they could

Iranian Supreme Leader Ali Khamenei has warned that Israel faces a ‘bitter and painful’ fate following the attack.

For much of the 20th century, the US and Iran maintained friendly relations. During the Cold War, Washington depended on the Shah of Iran to counter Soviet influence in the oil-rich Middle East.

Republicans and some Democrats offered strong support for Israel’s move, but many Democrats called for de-escalation and warned of the consequences of a broader war.

A statement released by Secretary of State Marco Rubio expressed no solidarity with Israel. The response may reflect a certain irritation with Netanyahu, who, by ordering the strikes, has undermined negotiations with Tehran that Trump relaunched in March.

Analysts believe that Iran may accelerate efforts to acquire a nuclear bomb as it faces a major Israeli assault.

The two sides were scheduled to meet for a sixth round of negotiations on Sunday. Oman, which was set to host the talks, said on Saturday that this round had been canceled.

The official tells Reuters that over 150 targets in Iran have been attacked. Most drones and missiles that have been launched towards Israel have been intercepted, the official says. Iranian state media has reported that 60 people, including 20 children, have been killed in an Israeli strike on Friday on a residential building in Tehran.